Structural analysis ofListerianeutral Sphingomyelinase (SmcL)
نویسندگان
چکیده
منابع مشابه
Crystal structure of SmcL, a bacterial neutral sphingomyelinase C from Listeria.
Sphingomyelinases C are enzymes that catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine. Various pathogenic bacteria produce secreted neutral sphingomyelinases C that act as membrane-damaging virulence factors. Mammalian neutral sphingomyelinases C, which display sequence homology to the bacterial enzymes, are involved in sphingolipid metabolism a...
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ISection for Medical Enzymology and Metabolism, Laboratory of Biochemistry, University of Amsterdam, P.O. Box 20151, 1000 lid Amsterdam, The Netherlands; 2Institute of Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagkstrasse i, D-5300 Bonn, Federal Republic of Germany; and 3Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Di...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2005
ISSN: 0108-7673
DOI: 10.1107/s0108767305092160